Nọmba Cas: 144701-48-4 Ụdị Molecular: C33H30N4O2

Nkọwa dị mkpirikpi:

Nọmba cas: 144701-48-4
Aha kemịkalụ:
Ụdị ihe omimi: C33H30N4O2

Okwu okwu:MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl))-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl) benzoic acid; 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazole]-1′-yl)methyl ][1,1'-biphenyl] -2-carboxylic acid, BIBR 277; PRITOR; BIBR 277; misartan; BIBR 277SE

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Nkọwapụta ngwaahịa

Ebe Na-agbaze	261-263°C
Njupụta	1.16 (ọnụahịa siri ike)
nchekwa okpomọkụ	Ọnọdụ ikuku na-adịghị arụ ọrụ, Okpomọkụ ụlọ 2-8 Celsius
solubility	DMSO:>5 mg/mL na 60 Celsius
ngwa anya ọrụ	N/A
Ọdịdị	Gbanyụọ-Ọcha siri ike
Ịdị ọcha	≥98%

Nkọwa

ewepụtara na US maka ọgwụgwọ ọbara mgbali elu.Enwere ike ịkwadebe ya na nzọụkwụ asatọ malite na methyl 4-amino-3-methyl benzoate;cyclization nke mbụ na nke abụọ n'ime mgbanaka benzimidazole na-eme na nzọụkwụ 4 na 6 n'otu n'otu.na-egbochi ọrụ nke angiotensin II (Ang II), molekul na-akpata isi nke sistemu renin-angiotensin-aldosterone (RAAS).Ọ bụ nke isii nke klaasị 《sartans》 ka a ga-ere ahịa ma ọ bụrụ na ọ gachara Losartan.Mmetụta ya na-adịte aka (ọkara awa 24) nwere ike ịbụ isi ihe dị iche na ndị ọzọ na-emegide angiotensin II.N'adịghị ka ọtụtụ ndị ọzọ nọ n'ụdị a, ọrụ ya anaghị adabere n'ịgbanwe ghọọ metabolite na-arụ ọrụ, 1-O-acylglucuronide bụ isi metabolite dị na mmadụ. angiotensin II mgbe enweghị mmekọrịta maka subtypes AT2 ma ọ bụ ndị nnabata ndị ọzọ na-etinye aka na usoro obi obi.N'ime ọtụtụ ọmụmụ ụlọ ọgwụ, n'otu usoro onunu ogwu kwa ụbọchị, na-emepụta mmetụta mbelata ọbara mgbali dị irè ma na-adịgide adịgide yana enwere mmetụta dị ala (karịsịa ụkwara metụtara ọgwụgwọ jikọtara ya na ndị na-egbochi ACE na ndị ọrịa agadi).