Nọmba Cas: 21187-98-4 Ihe oyiyi Molecular egosipụtara

Nọmba Cas: 21187-98-4 Ụdị Molecular

Nkọwa dị mkpirikpi:

Nọmba cas: 21187-98-4

Aha kemịkalụ:

Ụdị ihe omimi: C15H21N3O3S

Synonyms: BP; -4-methyl-; 1- (3-azabicyclo (3.3.0) oct-3-yl) -3- (p-tolylsulfonyl) urea; 1- (hexahydrocyclopenta (c) pyrrol-2 (1h). -yl) -3- (p-tolylsulfonyl) -ure; 1- (hexahydrocyclopenta (c) pyrrol-2 (1h) -yl) -3- (p-tolylsulfonyl) urea; benzenesulfonamide, n-(((hexahydrocyclopenta() c) pyrrol-2 (1h) -yl) amino) carbonyl; n- (4-methylbenzenesulfonyl) -n'-(3-azabicyclo (3.3.0) oct-3-yl) urea; Tetrabenzyl Voglibose HCl

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Nkọwapụta ngwaahịa

Ebe Na-agbaze	163-169 Celsius C
Njupụta	1.2205 (atụmatụ siri ike)
nchekwa okpomọkụ	Ọnọdụ ikuku na-adịghị arụ ọrụ, Okpomọkụ ụlọ 2-8 Celsius
solubility	methylene chloride: soluble
ngwa anya ọrụ	N/A
Ọdịdị	Gbanyụọ-Ọcha siri ike
Ịdị ọcha	≥98%

Nkọwa

bụ ihe nnọchi anya antihyperglycemic nke a na-eji maka ọgwụgwọ ọrịa shuga mellitus ụdị II.Ọ bụ klas sulfonylurea nke insulin secretagogues, nke na-akpali sel β nke pancreas ịhapụ insulin.na-ejikọta β cell sulfonyl urea receptor (SUR1), na-egbochikwa ọwa potassium nwere mmetụta ATP.Ya mere, mgbapụta potassium na-ebelata nke ukwuu, na-akpata mbibi nke mkpụrụ ndụ β.Mgbe ahụ, ọwa calcium na-adabere na voltaji na cell β na-emeghe, na-eme ka a rụọ ọrụ calmodulin, nke na-eduga na exocytosis nke insulin nwere granules nzuzo.Nnyocha e mere n'oge na-adịbeghị anya egosiwokwa na nwere ike imeziwanye ọnọdụ anti-oxidant na nitric oxide-mediated vasodilation na ụdị ọrịa shuga 2 ma chebe mkpụrụ ndụ beta pancreatic site na mmebi site na hydrogen peroxide.

ojiji na onunu ogwu

bụ ọgwụ hypoglycemic ọnụ nke a na-eji agwọ ọrịa shuga mellitus na-abụghị insulin na-adabere na ya. Ọgwụgwọ ọrịa shuga metụtara oke ibu ma ọ bụ ọrịa vaskụla, maka ndị okenye nwere ụdị ọrịa shuga 2. Ọrịa shuga bụ ọnọdụ ahụike na-adịghị ala ala (na-adịte aka) nke na-emetụta otú ahụ gị si atụgharị. nri n'ime ume.na-ebelata ọkwa glucose ọbara site na ịkpali mmepụta insulin site na sel β-sel nke agwaetiti Langerhans.