Nọmba Cetilistat Cas: 282526-98-1 Ụdị Molecular: C25H39NO3

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Nọmba cas: 282526-98-1

Aha kemịkal: Cetilistat

Ụdị ihe omimi: C25H39NO3

Okwu okwu: cetilistat Cetilistat (Alt-962) Cetilstat 2- (Hexadecyloxy) -6-methyl-4H-3,1-benzoxazin-4-otu

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nkọwapụta ngwaahịa

Ebe Na-agbaze	72.0 ruo 76.0 Celsius C
Njupụta	1.02
nchekwa okpomọkụ	A na-ekpuchi ya na akọrọ, 2-8 ° C
solubility	Chloroform (obere), ethyl acetate (obere)
ngwa anya ọrụ	N/A
Ọdịdị	Cryst na-acha ọcha
Ịdị ọcha	≥98%

pharmacodynamics

Cetilistat (nke a makwaara dị ka ATL-962) kwadoro na Septemba 2013 site na Ministry of Health, Labor and Welfare nke Japan maka ọgwụgwọ oke ibu, na-ejedebe na ndị ọrịa nwere ụdị ọrịa shuga mellitus 2 (T2DM) na dyslipidemia, yana oke ahụ. index (BMI) 25 n'arọ / m²n'agbanyeghị ọgwụgwọ nri na / ma ọ bụ mgbatị ahụ.Dị ka ọ dị na orlistat, cetilistat na-arụ ọrụ site na mgbochi nke pancreatic lipases n'ime eriri afọ iji gbochie nnabata abụba ma si otú a belata oriri caloric site na nri.A kọwaghị mmemme kemịkalụ ọgwụ na akwụkwọ sayensị, mana patent na-akọwa cetilistat na-akọwakwa njikọ nke analọg nwere ihe nnọchi aryl dị iche iche na ọdụ lipophilic.Njikọ nke cetilistat gụnyere condensation nke hexadecylcarbonochloridate na 2-amino-5-methylbenzoic acid;A na-emepụta analogs ndị ọzọ site na mgbanwe nke carbonochloridete na 2-aminobenzoic acid components.Cetilistat bụ ihe na-egbochi mmadụ na oke pancreatic lipase na IC_50snke 15 na 136 nM, n'otu n'otu, na obere mgbochi nke trypsin ma ọ bụ chymotrypsin.