Nọmba Cas: 330784-47-9 Ụdị Molecular: C23H26ClN7O3

Nkọwa dị mkpirikpi:

Nọmba cas: 330784-47-9

Aha kemịkalụ:

Ụdị ihe omimi: C23H26ClN7O3

Synonyms: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[(2-pyrimidinylmethyl)carbamoyl] pyrimidine

4-[(3-Chloro-4-methoxybenzyl) amino] -2-[2- (hydroxymethyl) -1-pyrrolidinyl] -N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide

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Nkọwa ngwaahịa

Mkpado ngwaahịa

Nkọwapụta ngwaahịa

Ebe Na-agbaze	150-152°C
Njupụta	1.372
nchekwa okpomọkụ	E mechiri ya na nkụ, chekwaa na friza, n'okpuru -20 Celsius
solubility	DMSO (obere), methanol (obere, ekpo ọkụ)
ngwa anya ọrụ	N/A
Ọdịdị	Ọcha ka Gbanyụọ-Ọcha
Ịdị ọcha	≥98%

pharmacodynamics

Ụlọ ọrụ ahụike Korea kwadoro (Zepeed) maka ọgwụgwọ nke nrụrụ erectile (ED) n'August 2011. bụ ihe na-emechi ụdị 5 phosphodiesterase (PDE5) nke ukwuu.A na-akọ na ọ bụ ihe mgbochi PDE5 kachasị ahọrọ na ahịa.Mmalite nke Tmax na ọkara ndụ dịkwa iche n'etiti ndị na-egbochi PDE5 a na-ere ahịa.Sildenafil nwere T_maxna 1 h na ọkara ndụ nke 3-5 h.Vardenafil yiri T_maxnke 0,6 h na ọkara ndụ nke 4-6 h.Tadalafil nwere ọkara ndụ kachasị ogologo n'etiti ọgwụ ndị a na-ere ahịa na ọkara ndụ nke 17 h.nwere mmalite ngwa ngwa na-erute T_maxna 0.6 h na ọkara ndụ nke 1.2 h.A kọwara njikọ nke (TA-1790) na akwụkwọ ikike ikike.Ụzọ bụ isi kpochapụ bụ site na bile na nsị.a chọpụtakwara na a na-emegharị ya site na recirculation enterohepatic.