Nọmba Cas: 147403-03-0 Ụdị Molecular: C24H29N5O3
| Ebe Na-agbaze | 230°C |
| Njupụta | 1.41g/cm³ |
| nchekwa okpomọkụ | 2-8 ℃ |
| solubility | Ọ fọrọ nke nta ka ọ ghara ịsacha ya na mmiri, na solubility na ethanol bụ 5.5 mg / m |
| ngwa anya ọrụ | +76.5 degrees (C=1, ethanol) |
| Ọdịdị | ọcha ma ọ bụ na-acha ọcha siri ike, enweghị isi |
bụ onye na-emegide ndị na-anabata peptide na-abụghị peptide, angiotensin II (AT).Ọ nwere nhọrọ dị elu n'akụkụ ụdị m nnabata (AT1) ma nwee ike ịsọ mpi na-enweghị mmetụta ọ bụla na-akpali akpali.Ọ nwekwara ike igbochi AT1 receptor mediated aldosterol ntọhapụ site na adrenal glomerular cell, ma ọ nweghị mmetụta mgbochi na ntọhapụ nke potassium kpatara, na-egosi mmetụta nhọrọ ya na ndị na-anabata AT1.Nnwale na vivo na ụdị anụmanụ ọbara mgbali elu dị iche iche egosila na ọ nwere mmetụta antihypertensive dị mma ma ọ nweghị mmetụta dị ukwuu na ọrụ nkwekọrịta obi na obi.Enweghị mmetụta antihypertensive na anụmanụ nwere ọbara mgbali nkịtị
Ọgwụ antihypertensive.bụ angiotensin II (Ang II) antagonist nke na-ahọrọ nke na-egbochi njikọ nke Ang II na ndị na-anabata AT1 (mmetụta mmegide ya kpọmkwem na ndị na-anabata AT1 dị ihe dị ka ugboro 20000 karịa nke AT2), si otú ahụ na-egbochi mkpụkọ vaskụla na ntọhapụ aldosterone, na-akpata ya. mmetụta hypotensive
Usoro mmalite nke akwadoro maka mbadamba nkume bụ 80mg (mbadamba 2), a na-ewere ọnụ otu ugboro n'ụbọchị.N'ozuzu, ọ bụrụ na ọ naghị arụ ọrụ maka izu 4, enwere ike ịbawanye dose ahụ ruo 160mg (mbadamba 4) otu ugboro n'ụbọchị.Dabere na data ngwa ụlọ ọgwụ mba ofesi, oke dose nwere ike iru 320mg (mbadamba 8) otu ugboro n'ụbọchị
1. Ndị ọrịa nwere ọbara mgbali elu gbagwojuru anya na ọrịa shuga, ọbara mgbali elu gbagwojuru anya na nephropathy ma ọ bụ ọrịa shuga nephropathy dị mfe,
2.ndị ọrịa nwere ọbara mgbali elu gbagwojuru anya na nkụda obi ma ọ bụ myocardial infarction
