l Cas nọmba: 171596-29-5 Molecular Formula: C₂₂H₁₉N₃O₄
| Ebe Na-agbaze | >193°C |
| Njupụta | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg / ml |
| nchekwa okpomọkụ | -20°C |
| solubility | DMF: 25 mg/ml DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml DMSO: 20 mg / ml |
| ngwa anya ọrụ | [α]/D +68 ruo +78°, c = 1 na chloroform-d |
| Ọdịdị | Ọcha ruo Gbanyụọ-Ọcha siri ike |
| Ịdị ọcha | ≥98% |
(Aha ahịa ma ọ bụ) bụ ụdị PDE5 inhibitor nke a na-eji agwọ ọrịa nrụrụ erectile, hypertrophy prostatic na-adịghị mma na ọbara mgbali elu pulmonary arterial.Mmetụta nke na-eme ka akwara dị n'ọbara dị jụụ ma na-amụba ọbara na-eruba n'ime corpus cavernosum.Usoro nke ime ihe bụ site na igbochi ọrụ nke cGMP kpọmkwem phosphodiesterase ụdị 5 (PDE5).PDE5 na-eweda cGMP na corpus cavernosum nke dị gburugburu amụ.Ya mere, tadalafi na-eduga n'ịba ụba nke cGMP nke na-eme ka ahụ ahụ dị nro na-eme ka ahụ dịkwuo mma na ịba ụba nke ọbara n'ime corpus cavernosum.Ụfọdụ ọmụmụ ụlọ ọgwụ gosikwara na nwere ike imeziwanye ọrụ endothelia n'ime ụmụ nwoke nwere nnukwu ihe ize ndụ nke obi ma belata mgbaàmà urinary tract nke abụọ na hyperplasia prostate benign.
analgesic, ihe mgbochi nnabata, agonist mu-opiod receptor.Ihe mgbochi phosphodiesterase 5.a na-eji maka ọgwụgwọ erectile dysfunction.
dị iche na nhazi ya na sildenafil na vardenafil.A na-etinye ya ngwa ngwa ma na-arị elu na ntinye uche (378 μg / L mgbe 20-mg dose gasịrị) mgbe awa 2 gachara, na-egosipụta ogologo ndụ ọkara nke awa 17.5.A na-emekwa ya metabolized site na imeju (CYP3A4).N'ụzọ doro anya, ọ bụghị mmanya na-aba n'anya ma ọ bụ iri nri ma ọ bụ ihe ndị dị ka ọrịa shuga ma ọ bụ ọrụ imeju ma ọ bụ gbasara akụrụ emetụtaghị ọgwụ ọgwụ ya.
